Homocysteine may build up in this new bloodstream when there is inadequate folate and/otherwise nutritional B
Neural tube defects (NTD) may result in anencephaly or spina bifida, which are mostly fatal congenital malformations of the central nervous system. The defects arise from failure of embryonic neural tube to close, which occurs between the 21 st and 28 th days after conception, a time when many women are unaware of their pregnancy (38). Randomized controlled trials have demonstrated 60% to 100% reductions in NTD cases when women consumed folic acid supplements in addition to a varied diet during the month before and the month after conception. Increasing evidence indicates that the homocysteine-lowering effect of folic acid plays a critical role in reducing the risk of NTD (39). a dozen for effective functioning of the methionine synthase enzyme. in B12 levels and elevated homocysteine concentrations have been found in the blood and amniotic fluid of pregnant women at high risk of NTD (40). The recent meta-analysis of 12 case-control studies, including 567 mothers with current or prior NTD-affected pregnancy and 1,566 unaffected mothers, showed that low maternal vitamin B12 status was associated with an increased risk of NTD (41). Yet, whether vitamin B12 supplementation may be beneficial in the prevention of NTD has not been evaluated (42).
Intellectual decline, alzhiemer’s disease, and you will Alzheimer’s disease
The occurrence of vitamin B12 deficiency prevails in the elderly population and has been frequently associated with Alzheimer’s disease (reviewed in 43). One study found lower vitamin B12 levels in the cerebrospinal fluid of patients with Alzheimer’s disease than in patients with other types of dementia, though blood levels of vitamin B12 did not differ (44). The reason for the association of low vitamin B12 status with Alzheimer’s disease is not clear. (more…)